Combigan contains which two active drugs?

• A. Brimonidine and Timolol
• B. Dorzolamide and Timolol
• C. Brimonidine and Latanoprost
• D. Timolol and Pilocarpine

Answer: (A)

Combigan blends two drugs to lower eye pressure by reducing the production of aqueous humor. One is brimonidine, an alpha-2 adrenergic agonist, and the other is timolol, a nonselective beta-blocker. Brimonidine mainly cuts outflow of fluid production, while timolol directly suppresses the ciliary body’s production of aqueous humor. Using them together gives an additive effect, often yielding a greater drop in intraocular pressure than either drug alone. The other options pair drugs that are not the combination found in Combigan: dorzolamide is usually paired with timolol in Cosopt, latanoprost is a prostaglandin analog used separately, and pilocarpine is a miotic. So the correct two active drugs in Combigan are brimonidine and timolol.