Dosing of fixed combinations without beta blockers when used as monotherapy is:

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Multiple Choice

Dosing of fixed combinations without beta blockers when used as monotherapy is:

Explanation:
Dosing fixed-dose combinations that do not contain a beta blocker is three times daily. The two components in these combinations, such as brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist), have relatively short durations of action in the eye. Without a prostaglandin analogue drift to provide once-daily effect, the combination needs frequent dosing to maintain steady 24-hour IOP reduction. Therefore, a thrice-daily schedule achieves consistent pressure lowering across the day.

Dosing fixed-dose combinations that do not contain a beta blocker is three times daily. The two components in these combinations, such as brinzolamide (a carbonic anhydrase inhibitor) and brimonidine (an alpha-2 agonist), have relatively short durations of action in the eye. Without a prostaglandin analogue drift to provide once-daily effect, the combination needs frequent dosing to maintain steady 24-hour IOP reduction. Therefore, a thrice-daily schedule achieves consistent pressure lowering across the day.

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