How much do ROCK inhibitors lower IOP?

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Boost your readiness for the Primary Open-Angle Glaucoma Test. Utilize flashcards and multiple-choice questions complete with hints and detailed explanations to enhance your understanding.

Multiple Choice

How much do ROCK inhibitors lower IOP?

Explanation:
ROCK inhibitors lower IOP mainly by increasing aqueous humor outflow through the trabecular meshwork, partly by relaxing the cytoskeleton of the outflow pathway (and they can also affect episcleral venous pressure). The typical absolute reduction is about 4 mmHg when starting IOP is in the mid-to-high 20s. So a drop from around 27 mmHg to roughly 22 mmHg matches the usual magnitude of effect. That’s why this option best reflects the expected change. A 2 mmHg drop is smaller than the common range, a 6 mmHg drop can occur in some cases but is less consistently observed, and saying there’s no measurable reduction contradicts the known effect.

ROCK inhibitors lower IOP mainly by increasing aqueous humor outflow through the trabecular meshwork, partly by relaxing the cytoskeleton of the outflow pathway (and they can also affect episcleral venous pressure). The typical absolute reduction is about 4 mmHg when starting IOP is in the mid-to-high 20s. So a drop from around 27 mmHg to roughly 22 mmHg matches the usual magnitude of effect. That’s why this option best reflects the expected change. A 2 mmHg drop is smaller than the common range, a 6 mmHg drop can occur in some cases but is less consistently observed, and saying there’s no measurable reduction contradicts the known effect.

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