Metabolic acidosis is a systemic side effect of oral CAIs. Which option correctly reflects this?

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Multiple Choice

Metabolic acidosis is a systemic side effect of oral CAIs. Which option correctly reflects this?

Explanation:
Metabolic acidosis is the systemic effect you’d expect from oral carbonic anhydrase inhibitors. These drugs block carbonic anhydrase in the kidney, especially in the proximal tubule, which reduces reabsorption of bicarbonate. The result is bicarbonate loss in the urine and a drop in serum bicarbonate, producing a non–anion gap metabolic acidosis. Hyperglycemia, hypertension, and hyperkalemia aren’t typical systemic effects of these agents (hypokalemia can occur due to increased potassium loss in the distal nephron, but not hyperkalemia). So metabolic acidosis best reflects the systemic side effect of oral CAIs.

Metabolic acidosis is the systemic effect you’d expect from oral carbonic anhydrase inhibitors. These drugs block carbonic anhydrase in the kidney, especially in the proximal tubule, which reduces reabsorption of bicarbonate. The result is bicarbonate loss in the urine and a drop in serum bicarbonate, producing a non–anion gap metabolic acidosis. Hyperglycemia, hypertension, and hyperkalemia aren’t typical systemic effects of these agents (hypokalemia can occur due to increased potassium loss in the distal nephron, but not hyperkalemia). So metabolic acidosis best reflects the systemic side effect of oral CAIs.

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