Netarsudil lowers IOP by increasing outflow through which structure?

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Multiple Choice

Netarsudil lowers IOP by increasing outflow through which structure?

Explanation:
Netarsudil lowers intraocular pressure by increasing drainage through the conventional aqueous humor outflow pathway. It’s a ROCK inhibitor that relaxes the actin cytoskeleton in trabecular meshwork cells, reducing stiffness and resistance at the juxtacanalicular region. This makes it easier for aqueous humor to move from the anterior chamber into the trabecular meshwork and then into Schlemm's canal, boosting outflow and lowering IOP. Schlemm's canal is downstream of the trabecular meshwork, so the primary site of action is the trabecular meshwork itself. The ciliary body and retina aren’t where this outflow increase occurs.

Netarsudil lowers intraocular pressure by increasing drainage through the conventional aqueous humor outflow pathway. It’s a ROCK inhibitor that relaxes the actin cytoskeleton in trabecular meshwork cells, reducing stiffness and resistance at the juxtacanalicular region. This makes it easier for aqueous humor to move from the anterior chamber into the trabecular meshwork and then into Schlemm's canal, boosting outflow and lowering IOP. Schlemm's canal is downstream of the trabecular meshwork, so the primary site of action is the trabecular meshwork itself. The ciliary body and retina aren’t where this outflow increase occurs.

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