True or False: We often increase dosing to achieve a greater IOP reduction.

• A. True
• B. False
• C. Not applicable
• D. Sometimes

Answer: (B)

In managing POAG, you aim to reach a target IOP while balancing efficacy and safety. Pushing the same eye drop to a higher dose or more frequent dosing does not usually yield proportional extra IOP lowering and often brings more side effects. Many drugs have a ceiling effect where additional increases in dose deliver only marginal gains, while the risk of ocular irritation, conjunctival hyperemia, or systemic effects rises with higher doses or more frequent use. Adherence also tends to suffer as regimens become more complex.

When the target IOP isn’t reached, the typical approach is to add another medication with a different mechanism or switch to a more potent option, rather than simply increasing the dose of the current one. In some cases, laser therapy or surgical interventions may be considered.