What is the additional mean IOP reduction for alpha-agonists?

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Multiple Choice

What is the additional mean IOP reduction for alpha-agonists?

Explanation:
Alpha-agonists give a modest additional drop in IOP when added to ongoing glaucoma therapy. They mainly decrease aqueous humor production by activating alpha-2 receptors in the ciliary body, and may slightly increase uveoscleral outflow, but the net effect is relatively small. On average, the extra reduction in IOP they provide is about 3 mmHg, though individual responses vary. So the best answer is 3 mmHg. Values like 7, 5, or 4 mmHg would indicate a larger additive effect than is typically observed with this drug class.

Alpha-agonists give a modest additional drop in IOP when added to ongoing glaucoma therapy. They mainly decrease aqueous humor production by activating alpha-2 receptors in the ciliary body, and may slightly increase uveoscleral outflow, but the net effect is relatively small. On average, the extra reduction in IOP they provide is about 3 mmHg, though individual responses vary. So the best answer is 3 mmHg. Values like 7, 5, or 4 mmHg would indicate a larger additive effect than is typically observed with this drug class.

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