What is the IOP reduction range for fixed combinations without beta blockers?

• A. 5-15%
• B. 21-35%
• C. 40-50%
• D. 60-70%

Answer: (B)

When evaluating how much an IOP drop to expect from fixed combinations that do not include a beta blocker, think in terms of percent reduction from baseline IOP. These non–beta-blocker fixed combinations blend two different mechanisms to lower IOP, so you get a meaningful, but not extreme, amount of lowering. Across clinical data, the typical range is in the low-to-mid twenties, with many patients falling between about 21% and 35% reduction. That’s why the correct range is 21-35%. To translate it practically: if a patient starts at a baseline IOP of, say, 26 mmHg, you’d commonly see roughly a 5–9 mmHg drop, which corresponds to about 20–35% reduction depending on the individual response.