What is the MOA of prostaglandin analogs?

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Multiple Choice

What is the MOA of prostaglandin analogs?

Explanation:
Prostaglandin analogs lower intraocular pressure mainly by increasing uveoscleral outflow, the unconventional drainage pathway. They activate FP receptors in the ciliary body and sclera, triggering remodeling of the extracellular matrix. This remodeling expands the spaces through which aqueous humor exits via the uveoscleral route, raising outflow and lowering pressure. They have minimal direct effect on aqueous humor production and do not primarily enhance trabecular outflow. This mechanism explains their strong IOP-lowering effect and why they’re often chosen as first-line therapy.

Prostaglandin analogs lower intraocular pressure mainly by increasing uveoscleral outflow, the unconventional drainage pathway. They activate FP receptors in the ciliary body and sclera, triggering remodeling of the extracellular matrix. This remodeling expands the spaces through which aqueous humor exits via the uveoscleral route, raising outflow and lowering pressure. They have minimal direct effect on aqueous humor production and do not primarily enhance trabecular outflow. This mechanism explains their strong IOP-lowering effect and why they’re often chosen as first-line therapy.

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