What is the MOA of cholinergic agonists?

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Boost your readiness for the Primary Open-Angle Glaucoma Test. Utilize flashcards and multiple-choice questions complete with hints and detailed explanations to enhance your understanding.

Multiple Choice

What is the MOA of cholinergic agonists?

Explanation:
Cholinergic agonists lower intraocular pressure by stimulating muscarinic receptors in the eye, causing the ciliary muscle to contract. This contraction pulls on the scleral spur and opens the angle of the trabecular meshwork, increasing aqueous humor outflow through the conventional pathway (via Schlemm’s canal). That’s why this mechanism best fits the action of these drugs. The other descriptions don’t reflect what these agents do: they don’t reduce outflow by iris sphincter contraction, they don’t relax the ciliary muscle to decrease production, and they don’t act by lowering episcleral venous pressure.

Cholinergic agonists lower intraocular pressure by stimulating muscarinic receptors in the eye, causing the ciliary muscle to contract. This contraction pulls on the scleral spur and opens the angle of the trabecular meshwork, increasing aqueous humor outflow through the conventional pathway (via Schlemm’s canal). That’s why this mechanism best fits the action of these drugs. The other descriptions don’t reflect what these agents do: they don’t reduce outflow by iris sphincter contraction, they don’t relax the ciliary muscle to decrease production, and they don’t act by lowering episcleral venous pressure.

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