When comparing target IOP from Tmax-based percent reduction and mmHg-range method, which target should you lean toward?

• A. Higher target
• B. Lower target
• C. Average of both
• D. No preference

Answer: (B)

Lower targets tend to offer better protection against glaucoma progression because reducing IOP more aggressively lowers the pressure-related stress on the optic nerve. When you derive a target from Tmax-based percent reduction, the absolute drop can be substantial, and in practice this can land you at a lower absolute value or, if not carefully managed, push you toward overly aggressive changes. The mmHg-range method provides a window, and choosing the lower end of that window adds an extra safety margin to protect the nerve while still being feasible for the patient. In most cases, aiming for the lower target balances the goal of neuroprotection with tolerability, making it the safer default choice when comparing the two methods.