Which class is typically represented by once-daily dosing in glaucoma therapy?

• A. Prostaglandin analogs
• B. Beta-blockers
• C. Carbonic anhydrase inhibitors
• D. Alpha agonists

Answer: (A)

Prostaglandin analogs are typically dosed once daily because they produce a strong and sustained reduction in intraocular pressure by increasing the outflow of aqueous humor through the uveoscleral pathway. This effect lasts roughly 24 hours, allowing a single daily dose—usually given in the evening—to maintain effective pressure control. The other classes generally have shorter durations of action or require more frequent dosing to maintain IOP lowering, such as twice daily for beta-blockers, and more frequent dosing for carbonic anhydrase inhibitors and alpha agonists. This long-lasting, once-daily profile is a defining feature of prostaglandin analogs in glaucoma therapy.