Which component of rocklatan is primarily associated with increasing trabecular outflow?

• A. Latanoprost 0.005%
• B. Netarsudil 0.02%
• C. Both components equally
• D. Neither component affects TM outflow

Answer: (B)

The main idea is that glaucoma meds work through different outflow pathways. Netarsudil, a ROCK inhibitor, reduces resistance in the trabecular meshwork, boosting the conventional (trabecular) outflow and helping aqueous humor drain through Schlemm’s canal. Latanoprost, a prostaglandin analog, mainly increases uveoscleral outflow by relaxing tissues in the ciliary body and sclera, not by enhancing the trabecular route. So the component that increases trabecular outflow is netarsudil. The other option (latanoprost) targets a different outflow pathway, and saying both components have the same effect or that neither affects the trabecular route isn’t accurate.