Which of the following is a prostaglandin analog commonly used in glaucoma therapy?

• A. Timolol
• B. Acetazolamide
• C. Latanoprost
• D. Pilocarpine

Answer: (C)

Prostaglandin analogs lower intraocular pressure mainly by increasing the outflow of aqueous humor through the uveoscleral pathway, and they’re typically prescribed as once-daily drops because of their strong efficacy and convenient dosing. Latanoprost is a prostaglandin F2α analog and is commonly used in glaucoma therapy for this purpose, making it a standard first-line choice. It works by enhancing uveoscleral outflow, leading to a reliable drop in pressure with relatively few systemic effects. The other drugs listed act through different mechanisms: timolol reduces aqueous humor production as a non-selective beta-blocker; acetazolamide inhibits carbonic anhydrase to lower production; pilocarpine is a cholinergic agent that increases outflow via the trabecular meshwork but is not a prostaglandin analog.