Which of the following is a systemic side effect associated with oral CAIs?

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Multiple Choice

Which of the following is a systemic side effect associated with oral CAIs?

Explanation:
Paresthesias, or tingling in the hands and feet, is a hallmark systemic side effect of oral carbonic anhydrase inhibitors used in POAG. These drugs (like acetazolamide) reach the whole body and disrupt bicarbonate handling, causing a mild metabolic acidosis and electrolyte shifts. That systemic disturbance frequently shows up as numbness or tingling in the extremities early in treatment or after dose increases. While nausea can occur with these medications, and other options listed are not typical systemic effects, the tingling in the extremities most clearly reflects the systemic impact of oral CAIs.

Paresthesias, or tingling in the hands and feet, is a hallmark systemic side effect of oral carbonic anhydrase inhibitors used in POAG. These drugs (like acetazolamide) reach the whole body and disrupt bicarbonate handling, causing a mild metabolic acidosis and electrolyte shifts. That systemic disturbance frequently shows up as numbness or tingling in the extremities early in treatment or after dose increases. While nausea can occur with these medications, and other options listed are not typical systemic effects, the tingling in the extremities most clearly reflects the systemic impact of oral CAIs.

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