Which of the following is a contraindication for oral CAIs?

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Multiple Choice

Which of the following is a contraindication for oral CAIs?

Explanation:
Oral carbonic anhydrase inhibitors lower intraocular pressure by inhibiting bicarbonate production in the ciliary body, but they can cause metabolic acidosis and electrolyte disturbances. In sickle cell disease, acidosis and dehydration promote red blood cell sickling and vaso-occlusion, making systemic CAIs contraindicated. The other conditions listed do not by themselves prevent use of oral CAIs: hypertension, diabetes mellitus, and penicillin allergy are not absolute contraindications.

Oral carbonic anhydrase inhibitors lower intraocular pressure by inhibiting bicarbonate production in the ciliary body, but they can cause metabolic acidosis and electrolyte disturbances. In sickle cell disease, acidosis and dehydration promote red blood cell sickling and vaso-occlusion, making systemic CAIs contraindicated. The other conditions listed do not by themselves prevent use of oral CAIs: hypertension, diabetes mellitus, and penicillin allergy are not absolute contraindications.

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