Which statement about data used to set target IOP is true?

• A. A single reading is enough
• B. Multiple untreated IOP measurements are needed
• C. Post-treatment measurements are required
• D. Only Tmax matters

Answer: (B)

Setting a target IOP depends on knowing the patient’s typical, untreated pressure and how much it can vary across the day. One reading isn’t enough because IOP fluctuates with time of day, posture, and measurement technique. Using data from multiple untreated measurements paints a more accurate baseline, letting you set a target that reflects the true pressure burden before any therapy and reduces the risk of over- or under-treating. Post-treatment measurements aren’t ideal for this purpose because they show the effect of treatment, not the patient’s natural baseline. And focusing only on the maximum IOP ignores overall exposure and diurnal variability, which are important for guiding target IOP. In short, combining several untreated IOP measurements provides a reliable foundation for setting a safe and effective target.