Which statement about Simbrinza is true?

• A. It is a fixed-dose combination that includes a beta blocker.
• B. It reduces IOP by exactly 4 mmHg in all patients.
• C. It contains brinzolamide and brimonidine.
• D. It is taken once daily.

Answer: (C)

Simbrinza is a fixed-dose combination eye drop used to lower intraocular pressure in open-angle glaucoma. It contains brinzolamide and brimonidine. Brinzolamide is a carbonic anhydrase inhibitor that reduces aqueous humor production, while brimonidine is an alpha-2 adrenergic agonist that both decreases production and can help increase outflow. Because it combines these two active ingredients, it does not include a beta blocker, so any statement claiming a beta blocker is included isn’t correct. The amount by which IOP is reduced varies between patients, so it’s not a universal exact drop like 4 mmHg for everyone. It is prescribed to be used twice daily, not once daily. Therefore, the true statement is that it contains brinzolamide and brimonidine.