Which statement correctly matches the terms long-term drift and short-term escape?

• A. Long-term drift: gradual rise in IOP with long-term use; Short-term escape: initial drop that returns to baseline within weeks
• B. Long-term drift: initial drop; Short-term escape: gradual rise
• C. Long-term drift: death of cells; Short-term escape: allergen
• D. Long-term drift: no effect; Short-term escape: increased IOP

Answer: (A)

The idea is about how glaucoma drugs can lose effectiveness over time. Long-term drift means the drug’s effect gradually wears off with prolonged use, so the intraocular pressure slowly increases despite continuing therapy. Short-term escape describes a situation where there is an initial drop in IOP after starting treatment, but the pressure climbs back toward baseline within a few weeks. So the correct pairing is: long-term drift = gradual rise in IOP with long-term use, and short-term escape = an early drop that returns to baseline within weeks. This helps explain why patients may need dose adjustments or switching therapies even when they initially respond well.