Which statement describes the components of Simbrinza?

• A. Brinzolamide and Brimonidine.
• B. Brinzolamide and Dorzolamide.
• C. Brimonidine and Latanoprost.
• D. Brimonidine and Timolol.

Answer: (A)

Simbrinza is a fixed-dose glaucoma eye drop that combines two drugs with complementary actions to lower intraocular pressure. One component is brinzolamide, a carbonic anhydrase inhibitor that acts in the ciliary body to reduce the formation of aqueous humor. The other component is brimonidine, an alpha-2 adrenergic agonist that also lowers aqueous humor production and can modestly enhance outflow. Using these two mechanisms together produces a greater overall drop in intraocular pressure than either drug alone.

The other pairings would mix drugs from different classes or duplicate a mechanism (for example, two carbonic anhydrase inhibitors or a prostaglandin analogue with another class, or a beta-blocker with brimonidine). The combination that matches Simbrinza is brinzolamide with brimonidine.