Which statement is true about response to beta-blocker therapy?

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Multiple Choice

Which statement is true about response to beta-blocker therapy?

Explanation:
Beta-blockers lower intraocular pressure by reducing aqueous humor production. In real-world practice, most patients experience a meaningful IOP drop, but not everyone responds adequately. About 10-20% of patients show little to no additional benefit from beta-blocker therapy, even with proper dosing and adherence. This reflects natural variability in how individuals respond to medications, and can be influenced by factors like tachyphylaxis with long-term use. Therefore, the statement that 10-20% do not respond best captures the expected range of nonresponse. The other options exaggerate or understate the true variability in response.

Beta-blockers lower intraocular pressure by reducing aqueous humor production. In real-world practice, most patients experience a meaningful IOP drop, but not everyone responds adequately. About 10-20% of patients show little to no additional benefit from beta-blocker therapy, even with proper dosing and adherence. This reflects natural variability in how individuals respond to medications, and can be influenced by factors like tachyphylaxis with long-term use. Therefore, the statement that 10-20% do not respond best captures the expected range of nonresponse. The other options exaggerate or understate the true variability in response.

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