Which term refers to the initial IOP reduction from beta-blockers that tends to return to baseline within a few weeks?

• A. Long-term drift
• B. Short-term escape
• C. Tolerance
• D. Rebound

Answer: (B)

Short-term escape describes the phenomenon where the initial IOP-lowering effect of a topical beta-blocker wanes and IOP returns toward baseline within a few weeks, even though the medication is continued. This reflects a temporary loss of the drug’s effect rather than a complete failure of therapy. It differs from broader tolerance, which is a more general, gradual reduction in response that develops with ongoing exposure over a longer period. Long-term drift implies gradual changes in IOP over months or years due to disease progression or other factors, not a short-lived rebound of effect. Rebound would mean IOP rises after stopping the medication, not while it’s being used.